منابع مشابه
Targeting molecular networks for drug research
The study of molecular networks has recently moved into the limelight of biomedical research. While it has certainly provided us with plenty of new insights into cellular mechanisms, the challenge now is how to modify or even restructure these networks. This is especially true for human diseases, which can be regarded as manifestations of distorted states of molecular networks. Of the possible ...
متن کاملMolecular Pathways: Targeting ATR in Cancer Therapy.
The human ATR gene encodes a kinase that is activated by DNA damage and replication stress as a central transducer of a checkpoint signaling pathway. Once activated, ATR phosphorylates multiple substrates, including the kinase Chk1, to regulate cell-cycle progression, replication fork stability, and DNA repair. These events promote cell survival during replication stress and in cells with DNA d...
متن کاملApoptosis and Molecular Targeting Therapy in Cancer
Apoptosis is the programmed cell death which maintains the healthy survival/death balance in metazoan cells. Defect in apoptosis can cause cancer or autoimmunity, while enhanced apoptosis may cause degenerative diseases. The apoptotic signals contribute into safeguarding the genomic integrity while defective apoptosis may promote carcinogenesis. The apoptotic signals are complicated and they ar...
متن کاملMolecular Pathways Molecular Pathways: Targeting ATR in Cancer Therapy
The humanATR gene encodes a kinase that is activated byDNA damage and replication stress as a central transducer of a checkpoint signaling pathway. Once activated, ATR phosphorylates multiple substrates, including the kinase Chk1, to regulate cellcycle progression, replication fork stability, andDNA repair. These events promote cell survival during replication stress and in cells with DNA damag...
متن کاملMolecular Targeted Drug Therapy of Ovarian Cancer
Molecular targeted therapy as a new means of cancer therapy targeting molecular pathological abnormalities of cancer, the use of target binding ligand and receptor can effectively improve drug lethal to tumor cells while reducing adverse effects on normal tissues and organs, it has been gradually used in clinical treatment. In the treatment of ovarian cancer in comparison with conventional trea...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2012
ISSN: 0923-7534
DOI: 10.1016/s0923-7534(20)32100-1